Registration Dossier
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EC number: 225-805-6 | CAS number: 5089-70-3
Endpoint summary
Administrative data
Description of key information
In the key in vivo skin and eye irritation studies for (3-chloropropyl)triethoxysilane (DCC, 1995c and DCC, 1995d), the substance was not irritant to rabbit skin or eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The key skin and eye irritation studies were selected as the only available studies for these endpoint that were carried out in accordance with the relevant OECD test guideline and GLP (reliability 1). A further study for each endpoint complying with an EPA guideline and GLP (also reliability 1) found mild and transient skin and eye irritation. Several non-guideline and/or non-GLP Reliability 2 studies (four in the case of skin irritation and three for eye irritation) were also available. All these studies supported the classification not irritant to the skin and eyes of the key studies.
Justification for classification or non-classification
Based on reliable in vivo skin and eye irritation data, (3 -chloropropyl)triethoxysilane does not meet the criteria for classification as irritant according to EU Directive 67/548/EEC and Regulation 1272/2008.
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