Registration Dossier
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EC number: 225-805-6 | CAS number: 5089-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study (DCC, 1995a) an LD50 >2000 mg/kg was determined for male and female rats in a study that was conducted according to OECD 401 and in compliance with GLP. Clinical signs were limited to soft stools and anogenital staining. No abnormalities were detected at necropsy.
In the key acute dermal study (DCC, 1995b) an LD50 >2000 mg/kg was determined for rats. There were no clinical signs of toxicity or necropsy findings.
No data are available for the inhalation route.
Key value for chemical safety assessment
Additional information
The key acute oral toxicity study (DCC, 1995a) was selected from five studies of reliability 1 or 2. Three other studies (at higher dose levels than current guidelines require) support the conclusion of the key study that LD50(oral) for rats is >2000 mg/kg (Degussa 1980; Consultox Labs 1976; Osi, 1996). In the fifth study, which was limited in respect of the amount of experimental detail available, an LD50of 1297 mg/kg was reported (Unknown, 1975). However, since four more recent studies clearly show LD50values in excess of 2000 mg/kg, this result has not been used for classification.
The key acute dermal toxicity study was selected from three Reliability 1 guideline studies, all in compliance with GLP and OECD 402 or similar. All studies gave LD50>2000 mg/kg bw for rats or rabbits.
Justification for classification or non-classification
Based on the available data for the oral and dermal routes, (3 -chloropropyl)triethoxysilane is not classified for acute toxicity according to EU Directive 67/548/EEC and Regulation 1272/2008. No data are available for the inhalation route.
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