Registration Dossier
Registration Dossier
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EC number: 219-291-2 | CAS number: 2403-88-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Medaka
- Source: Obtained from commercial domestic hatcheries - Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Test temperature:
- 23.9 - 24.8 °C.
- pH:
- 8.7 - 10.0
- Dissolved oxygen:
- 6.4 - 8.1 mg/L.
- Nominal and measured concentrations:
- 0, 87.5, 114, 148, 192, 250, 325, 423 mg/L
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 237 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
– Lowest test substance concentration causing 100 % mortality: 325 mg/L
– Mortality of controls: No mortality observed during test period.
– Abnormal responses: Not stated.
– Reference substances (if used) – results: Not described.
– Any observations: No precipitates and colour formation by the test chemical.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hours LC50 for Medaka (Oryzias latipes) exposed to 2,2,6,6-Tetramethylpiperidin-4-ol is 237 mg/L from the concentration-response curve.
Reference
Description of key information
The key study regarding acute toxicity for fish (medaka) shows a LC 50 (96h) of 237 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 237 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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