Registration Dossier
Registration Dossier
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EC number: 231-760-3 | CAS number: 7722-64-7
Endpoint summary
Administrative data
Description of key information
Corrosive on the skin of rabbit. Full thickness destruction of skin tissue was observed 4h after application of 0.5 g of the test substance.
Fully reversible after approximately 14 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The test substance Potassium permanganate was tested for acute dermal irritation/corrosion. After 4-hour exposure of the test substance on the intact skin of the test animal, full thickness destruction of skin tissue occurs. Then the testing was stopped – no other animal was used. No extinction of corrosive lesions was recorded in 72 hours after exposure, the test animal was then observed until the end of observation period (14 days). During the 14-day observation period, the lesions on the skin were almost healed without complications. No other signs of intoxication were observed.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Regarding the corrosive classification, we have classified potassium permanganate as non-corrosive since 1996, based on the test results using Corrositex, a non-animal test method, http://corrositex.com/ . Corrositex is a non-animal alternative toxicology test. Although not a classical "in vitro" test, Corrositex uses a synthetic membrane-based detection system to determine the UN packing group classification of chemicals, consumer products or other hazardous materials. The results, expressed as a break-through time, correlate well with rabbit dermal corrosivity tests. This test method Corrositex, IVRO's dermal corrosion testing assay, is accepted or approved by a large number of regulatory agencies including DOT, EPA, EU/OECD, European Centre for the Validation of Alternative Methods (ECVAM), OSHA, FDA, Consumer Product Safety Commission, Transport Canada, and IATA as a replacement for Draize testing. This test in our view accurately reflects the effect of potassium permanganate rather than potassium hydroxide, the corrosive by-product.
However, due to GHS, most countries including Japan and Korea have classified potassium permanganate as a corrosive, over which we don’t have any control, and we may have to classify potassium permanganate as corrosive in the EU also.
Even though potassium permanganate itself is not corrosive, due to its reactivity with biological materials, including skin, the by-product (potassium hydroxide) causes skin corrosion and we would classify potassium permanganate as corrosive to protect human health.
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