Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-302-7 | CAS number: 1120-24-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- For details on endpoint-specific justification, please see read-across justification document (category approach) in the linked category of dimethylalkylamines.
Data source
Materials and methods
Test material
- Reference substance name:
- Decyldimethylamine
- EC Number:
- 214-302-7
- EC Name:
- Decyldimethylamine
- Cas Number:
- 1120-24-7
- Molecular formula:
- C12H27N
- IUPAC Name:
- decyldimethylamine
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: no effects observed
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 22 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.23
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 22 days
Any other information on results incl. tables
Results presented above were obtained with the source substance C16-DMA.
Additional results for C16-DMA:
Mean valuea for occulat lesions 24, 48 and 72 h after instillation
| Animal number and sex | Corneal opacity | Iridial lesions | Redness of Conjunctiva | Chemosis |
| 27TK490F | 0 | 1 | 1 | 2 |
| 27TK533F | 0 | 1 | 1 | 0,7 |
| 27TK534F | 0 | 0 | 1 | 1 |
Grades for occular irritation responses
Animal No. and Sex: 27TK490F# | Pain evaluation response: 0 |
|
|
| ||||
Region of | Response |
| Grade of response at time alter instillation Hours Days |
| ||||
1 | 24 | 48 | 72 | 8 | 15 | 22 | ||
Comea | Opacity | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Area | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ulceration |
|
|
|
|
|
|
|
| Stippling |
|
|
|
|
|
|
|
Iris | Value | 1 | 1 | 1 | 1 | 0 | 0 | 1 |
Conjunctiva | Redness | 2 | 1 | 1 | 1 | * | * | 1 |
| Chemosis | 0 | 2 | 2 | 2A | OA | OA | 0 |
| Discharge | 2 | 1 | 1 | 2 | * | * | 1 |
| Necrosis | - |
|
|
|
|
|
|
| Ulceration | - | - |
|
|
|
|
|
| BC | BC | |||||||
Grades for occular irritation responses
Animal No. and Sex: 27TK534F | Pain evaluation response: 0 |
|
|
| ||||
Region of | Response |
| Grade of response at time alter instillation Hours Days |
| ||||
1 | 24 | 48 | 72 | 8 | 15 | 22 | ||
Cornea | Opacity | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Area | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ulceration |
|
|
|
|
|
|
|
| Stippling |
|
|
|
|
|
| - |
Iris | Value | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Conjunctiva | Redness | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Chemosis | I | 2A | IA | OA | OA | OA | 0 |
| Discharge | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Necrosis |
|
|
|
|
|
|
|
| Ulceration |
|
|
|
|
|
|
|
| BC | BC | |||||||
#Sentinel animal
* Impossible to open eye sufficiently to assess
A Blepharitis
B Peri-orbital exfoliation
C Peri-orbital hair loss
Applicant's summary and conclusion
- Executive summary:
The study used as source investigated eye irritation/corrosion of C16-DMA. The study results of the source compound were considered applicable to the target compound. Justification and applicability of the read-across approach (category approach) is outlined in the read-across report in the linked category of dimethylalkylamines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
