Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited documentation; case report
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Phosphorus trichloride exposure - A follow up study of 27 exposed patients
- Author:
- Wason S, Gomolin I, Gross P & Lovejoy FH
- Year:
- 1 982
- Bibliographic source:
- Vet. Hum. Toxicol. 24, 17-18
- Reference Type:
- publication
- Title:
- Phosphorus trichloride toxicity
- Author:
- Wason S, Gomolin I, Gross P, Mariam S & Lovejoy FH
- Year:
- 1 984
- Bibliographic source:
- Am. J. Med. 77, 1039-1042
Materials and methods
- Type of study / information:
- Health effects following accidental exposure
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of health effects following accidental exposure
- GLP compliance:
- no
- Remarks:
- : not applicable
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- phosphorus trichloride
Constituent 1
Method
- Details on study design:
- Investigation of health effects following accidental exposure
- Exposure assessment:
- not specified
Results and discussion
- Results:
- Patients accidentally were exposed to PCl3 and its degradation products after a railroad accident. Symptoms of exposure included burning eyes (85%; mild conjunctivitis in 36%), shortness of breath (59%), throat irritation (59%) and lacrimation (59%), headache and nausea (48%), burning skin (44%), sputum production (41%), generalized or pleuritic chest pain (33%) and rash/itch (33%), wheezing (26%), blurred vision (22%), vomiting (15%) and abdominal pain (15%). Lactic dehydrogenase was increased in 22% of patients and recovered within four weeks after exposure. Pulmonary function tests showed a decrease of vital capacity in patients within 1/8 mile of the event. Hypoxaemia was recorded in these patients after two months.
Applicant's summary and conclusion
- Executive summary:
Patients accidentally were exposed to PCl3 and its degradation products after a railroad accident. Symptoms of exposure included burning eyes (85%; mild conjunctivitis in 36%), shortness of breath (59%), throat irritation (59%) and lacrimation (59%), headache and nausea (48%), burning skin (44%), sputum production (41%), generalized or pleuritic chest pain (33%) and rash/itch (33%), wheezing (26%), blurred vision (22%), vomiting (15%) and abdominal pain (15%). Lactic dehydrogenase was increased in 22% of patients and recovered within four weeks after exposure. Pulmonary function tests showed a decrease of vital capacity in patients within 1/8 mile of the event. Hypoxaemia was recorded in these patients after two months.
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