Aziridine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: study report which meets basic scientific principles, acceptable with restrictions (limited documentation, vapour exposure of several animal species in one container)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Principles of method if other than guideline:

BASF-Test

GLP compliance:

no

Test type:

other: Exposure to static test substance vapour atmosphere

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethylenimine

IUPAC Name:

Ethylenimine

Details on test material:

- Name of test material (as cited in study report): TH 14 151/OX "Rest aus Aethylenimin-Leitung"
- Physical state: liquid
- Composition: 94.1 % ethylenimin; 4.0 % water; 0.68 % low boiling fraction (ammonia, methylamine), 1.8 % higher boiling fraction (ethylenediamine, dimeric ethylenimine), < 0.001 % sulfur.

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

TEST ATMOSPHERE
The vapour saturation was calculated based on the vapour pressure at 20 °C and the molecular weight.
Vapour saturation = 286.42 mg/L at 20 °C.
Thus, it can be concluded that the animals in the present study were indeed exposed to test substance vapours and no aerosol.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

30 min

Concentrations:

approx. 1.8 mg/L

No. of animals per sex per dose:

5 animals/dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations, body weight determnation at test start
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, organ weights

Statistics:

No statistics were performed.

Results and discussion

Effect levels

Dose descriptor:

LC50

Effect level:

> 1.8 other: mg/L

Exp. duration:

30 min

Remarks on result:

other: A LC50 was not determined in this study

Mortality:

1 of 5 rats died 6 days after exposure to the test substance vapours.

Clinical signs:

other: The rats did not show any overt signs of toxicity.

Body weight:

no data

Gross pathology:

The deceased rat showed renal papillary necrosis. In the animals sacrificed at the end of the observation period of 14 days no abnormalities were observed at necropsy.