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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific standards, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1961
Reference Type:
other company data
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Principles of method if other than guideline:
BASF test
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Ethylenimine
IUPAC Name:
Ethylenimine
Details on test material:
- Name of test material (as cited in study report): Aethylenimin (commercial product)
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
other: Vienna White and Russian
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.8, 2.54, 2.59, 2.22, 2.12, 2.13 kg


ENVIRONMENTAL CONDITIONS
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): undiluted, no amount specified
Duration of treatment / exposure:
1 min, 5 min, 15 min
Observation period:
8 days
Number of animals:
3 animals (5 min, 15 min), 6 animals (1 min)
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: patch, no further data


REMOVAL OF TEST SUBSTANCE
- Washing: yes (exposure 1, 5, 15 min) first with undiluted Lutrol 9, then with an aqueous Lutrol solution (50 %)
- Time after start of exposure: 1, 5, and 15 min, respectively


SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 1.5 hours
Score:
3 - 4
Max. score:
4
Reversibility:
other: animals died within 24 hours after application
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 1.5 hours
Score:
3
Max. score:
4
Reversibility:
other: animals died within 24 hours after application
Irritant / corrosive response data:
Anemic area, black-brown, blood discharge, necrosis within 1.5 hours after application.
Other effects:
Clinical signs of toxicity: rolling convulsions, tonic convulsions, mydriasis, atony, accelerated respiration, death

Any other information on results incl. tables

Both animals died within 24 hours after application of the undiluted test substance for 1, 5, and 15 min, respectively. Based upon the observed findings, ethylenimine can be estimated to be corrosive and very toxic by skin contact.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information