Registration Dossier
Registration Dossier
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EC number: 204-482-5 | CAS number: 121-57-3
Endpoint summary
Administrative data
Description of key information
Additional information
For each of the three species fish, daphnia and algae, representing three trophic levels, one reliable acute toxicity study was available.
Consequently, these studies were considered as key studies.
The acute toxicity of the test substance to fish was investigated in a study according to OECD test guideline 203 under GLP. In a 96h static limit test, the test concentration 100 mg/L was used. Using a validated photometric method, agreement of nominal and measured concentrations was confirmed. All validity criteria were fulfilled. Based on mortality, the EC50 (96h) was determined to be > 100 mg/L.
As the substance is found to be readily biodegradable and the applied test concentrations (see Chapter 5.2.1: concentrations range from 0.1 to 2.5 g/L), which are not toxic, are in the range of concentrations that can be expected in the influent of a sewage treatment plant, activated sludge respiration testing is not required. Conservatively, the NOEC of 1 g/L will be assumed for PNEC derivation.
The acute toxicity of the test substance to Daphnia magna was investigated in a study according to OECD test guideline 202 under GLP. In a 48h static test, five test concentrations (10 / 18 / 32 / 56 / 100 mg/L) were tested. Using a validated photometric method, agreement of nominal and measured concentrations was confirmed. All validity criteria were fulfilled. Based on mobility, the EC50 (48h) was determined to be 23 mg/L.
The toxicity of the test substance toDesmodesmus subspicatuswas investigated in a study according to OECD test guideline 201 under GLP. In a 72h test, five test concentrations (4.6 /10 / 22 / 46 / 100 mg/L)were tested. Using a validated photometric method, agreement of nominal and measured concentrations was confirmed. All validity criteria were fulfilled. Based on cell numbers, the EC50 (72h) was determined to be 32 mg/L with a corresponding NOEC of 4.6 mg/L.
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