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EC number: 485-260-7 | CAS number: 927395-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD/EU guideline study conducted to the principles of good laboratory practice
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Pre-study solubility work indicated that it was not possible to obtain a testable solution of the test material using traditional methods (e.g. ultrasonication, high-shear mixing). The test material is poorly water soluble and known to rapidly degrade in water to give t-butyldimethylsilanol and 3-(dimethoxymethylsilyl)-propane-1-thiol. As such, and in accordance with the OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures (OECD 23, 2000), it was considered appropriate to expose the test organisms to the test material degradation products. Due to the volatility of 3-(dimethoxymethylsilyl)-propane-1-thiol, chemical analysis of the test preparations was conducted for t-butyldimethylsilanol alone.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Nominal concentrations of 10, 18, 32, 56, and 100% v/v saturated solution
Semi-static test with complete renewal of medium every 24h. Media analysed at start and end of each 24h period.
Concentrations of t-butyldimethylsilanol were as follows
0h (new): 23.9, 45.5, 72.1, 129, 241mg/l respectively
24h (old): 22.9, 44.3, 75.4, 131, 234mg/l respectively
24h (new): 24.7, 43.8, 76.8, 258mg/l respectively (56% nominal not analysed)
48h (old): 20.8, 36.2, 68.2mg/l respectively (56% & 100% nominal not analysed)
48h (new): 24.5, 44.2, 79.3, 262mg/l respectively (56% nominal not analysed)
72h (old): 23.5, 33.5, 70.7mg/l respectively (56% & 100% nominal not analysed)
72h (new): 26.0, 44.2, 68.9, 218mg/l respectively (56% nominal not analysed)
96h (old): 20.6, 29.7, 63.7mg/l respectively (56% & 100% nominal not analysed)
Test solutions
- Vehicle:
- no
- Details on test solutions:
- An amount of test material (11.25g) was dispersed in 22.5l of dechlorinated tap water using a propellor stirrer at approximately 1500rpm at 14°C for 24h. Undissolved test material was removed via filtration through a 0.2µm Sartorius Sartopore filter, with the initial 500ml being discarded to precondition the filter, to produce a 100% v/v saturated solution of the test material degradation products, which was also the highest test concentration. A sample was immediately taken for chemical analysis. Aliquots of the saturated solution (2.0, 3.6, 6.4, and 11.2l) were then further diluted to 20l, by mixing with a flat-bladed mixer for 1min, to prepare the remainder of the test series.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Supplier: Brow Well Fisheries Ltd, Hebden, near Skipton, Yorkshire, UK
Juveniles were maintained in a glass fibre tank with a single pass water renewal system. There was less than 1% mortality in the stock fish population during the 7 days prior to the start of the test. They were fed commercial trout pellets that were discontinued approximately 24h prior to the start of the definitive test. Test fish had a mean standard length and weight of 5.6cm and 2.69g at the end of the definitive test. They were acclimatised to test conditions from 15 July 2009 to 26 July 2009.
Test conditions: 16h/8h light/dark lighting cycle with 20min dawn/dusk transition periods; 14°C; dissolved oxygen 8.8mgO2/l; water hardness approximately 140mg/l as CaCO3.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- ca. 140mg/l as CaCO3
- Test temperature:
- 14°C
- pH:
- 7.6-8.0
- Dissolved oxygen:
- 8.8mg/l
- Nominal and measured concentrations:
- Nominal concentrations: 10%, 18%, 32%, 56%, 100% saturated solution
Concentrations of t-butyldimethylsilanol were as follows
0h (new): 23.9, 45.5, 72.1, 129, 241mg/l respectively
24h (old): 22.9, 44.3, 75.4, 131, 234mg/l respectively
24h (new): 24.7, 43.8, 76.8, 258mg/l respectively (56% nominal not analysed)
48h (old): 20.8, 36.2, 68.2mg/l respectively (56% & 100% nominal not analysed)
48h (new): 24.5, 44.2, 79.3, 262mg/l respectively (56% nominal not analysed)
72h (old): 23.5, 33.5, 70.7mg/l respectively (56% & 100% nominal not analysed)
72h (new): 26.0, 44.2, 68.9, 218mg/l respectively (56% nominal not analysed)
96h (old): 20.6, 29.7, 63.7mg/l respectively (56% & 100% nominal not analysed) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 20l, glass exposure vessels, covered to reduce evaporation
- Aeration: via narrow bore glass tubes
- Renewal rate of test solution (frequency/flow rate): 24h (semi-static test)
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.94g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water dechlorinated by passage through activated carbon filter (Purite Series 500) and partly softened (Elga Nimbus 1248D Duplex Water Softener)
OTHER TEST CONDITIONS
- Adjustment of pH: not applicable
- Photoperiod: 16h/8h light/dark cycle with 20min transition periods
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortalities and sublethal effects of exposure were recorded at 3, 6, 24, 48, 72, and 96h after the start of exposure. The criteria of death were taken to be the absence of both respiratory movement and response to physical stimulation. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 26 other: % v/v
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95%CL=22-30%
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 18 other: % v/v
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No deaths occurred during the study at 0%, 10%, or 18% nominal. 0% mortality.
At 32% nominal, there were 6/7 found moribund after 0.5h exposure. These fish were killed and classed as mortalities for the following (3h) observational time point. 86% mortality.
All 7 fish were found dead after 0.5h exposure at the 56% and 100% nominal concentration levels. 100% mortality. - Reported statistics and error estimates:
- Lc50 and CL were calculated by the trimmed Spearman-Karber method using ToxCalc computer software
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Given that the test organisms were exposed to a mixture of degradation products and that toxicity cannot be attributed to a single degradation product or mixture of such products but to the test material and its degradation products as a whole, the results are based on the nominal test material degradation products concentrations only.
The 96h LC50 is 26% v/v (95% CL 22-30% v/v). The NOEC is 18%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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