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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only result is given with very limited information on experimental details

Data source

Reference
Reference Type:
publication
Title:
Cancerogene alkylierende Substanzen: IV. 1,3-Propansulton und 1,4-Butansulton
Author:
Druckrey, H. et al.
Year:
1970
Bibliographic source:
Z. Krebsforsch. 75, 69-84

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-propanesultone
EC Number:
214-317-9
EC Name:
1,3-propanesultone
Cas Number:
1120-71-4
Molecular formula:
C3H6O3S
IUPAC Name:
1,2λ⁶-oxathiolane-2,2-dione
Details on test material:
- Name of test material: 1,3-Propansulton
- Molecular weight: 122.1
- Substance type: colorless, crystalline
- Physical state:solid

Test animals

Species:
rat
Strain:
other: BD
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
210 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion