Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
INITIAL SUBMISSION: TOXICITY STUDIES OF 1,2-OXATHIOLANE,2,2-DIOXIDE WITH COVER LETTER DATED 09/01/92
Author:
OTS
Year:
1992
Bibliographic source:
Microfiche No. OTS0555330 , Doc ID 88-920009014

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not applicable
Principles of method if other than guideline:
- 3 rats were whole body exposed to the test item (2-3 L/min through an open-end bubbler at 97 °C) for 6 hours
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-propanesultone
EC Number:
214-317-9
EC Name:
1,3-propanesultone
Cas Number:
1120-71-4
Molecular formula:
C3H6O3S
IUPAC Name:
1,2λ⁶-oxathiolane-2,2-dione
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Type of exposure:
2-3 L/min through an open-end bubbler at 97 °C (chamber temperature 28-28.5 °C)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
2.14 mg /L (425 ppm)

1.3 mg/L (260 ppm)
No. of animals per sex per dose:
3 rats per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 8 days
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC100
Effect level:
2.14 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: 2/3 animals died after 24 h, 3/3 animals died in 8 days
Sex:
not specified
Dose descriptor:
LC0
Effect level:
1.3 mg/L air
Based on:
test mat.
Exp. duration:
6 h
Mortality:
After being expsosed to 2.14 mg/L for 6 hours 2/3 animals died after 24 h, 3/3 animals died within 8 days and 0/3 animals died after exposure to 1.3 mg/L.
Clinical signs:
other: At 2.14 mg/L group: Piloerection and vasodilation: after 3 min Blepharism: after 5 min Lacrimation: 25 min At 1.3 mg/L group: Piloerection: after 5 min Vasodilation: after 15 min Blepharism: after 60 min Lacrimation: 80 min
Body weight:
At 1.3 mg/L group:
weight gain of 115 grams on average

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
CLP: Acute Inhal 4, H332