Phthalimide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Remarks:

During exposure period sample changed from fine, white powder to light tan crystalline solid. No analytics on exposure concentration. Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

Phthalimide - CAS No: 85-41-6

Author:

OECD SIDS

Year:

2005

Bibliographic source:

SIDS Initial Assessment Report for 20th SIAM, UNEP Publications

Reference 2

Reference Type:

other company data

Title:

Unnamed

Year:

1970

Materials and methods

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phthalimide

EC Number:

201-603-3

EC Name:

Phthalimide

Cas Number:

85-41-6

Molecular formula:

C8H5NO2

IUPAC Name:

1H-isoindole-1,3(2H)-dione

Details on test material:

phthalimide heated to 150 degree Celsius

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Duration of exposure:

6 h

No. of animals per sex per dose:

6

Results and discussion

Any other information on results incl. tables

Amount of vaporized phthalimide: 0.0 g(amount of sample at start and end: 56.2 g). 
During exposure period sample changed from fine, white  powder to light tan 
crystalline solid.

Animal no./sex           fate            observations during exposure
1 /male                 survived                    no immediate  effect
2 /male                 survived                    normal reaction
3 /male                 survived                    no discharge
4 /male                 survived                    no weaknes
5 /male                 survived 
6 /male                 survived 

All animals survived the ten days observation period; the vapors were  
practically non-toxic.
The ten days observation period was uneventful. 
The viscera appeared  normal by microscopic examination.