Registration Dossier
Registration Dossier
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EC number: 500-004-7 | CAS number: 9003-29-6
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
No carcinogenicity tests have been conducted on C6-C18 alpha or internal olefins. However, there
are no structural alerts indicating a potential for carcinogenicity in humans.
For analogy, long-term carcinogenicity studies have been conducted for alpha olefin sulfonates (AOS) derived from alpha olefins of similar alkyl length. For example, Hunter and Benson (1976) fed rats mixed C14-16 AOS at dietary levels of 1000, 2500, and 5000 ppm for two years.
Blood chemistries, urinalyses, and histopathological findings were comparable to control values.
There was no increase in tumors from the feeding of the test article.
Three carcinogenicity studies of AOS reported by Oba and Takei (1992) indicated that these AOS were not carcinogenic by oral or dermal routes.
Furthermore, negative results were seen in UDS and transformation assays concucted with Hexene, Octene,
C12 -16 olefin fraction, Tetradecene, and Hexadecene.
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