Registration Dossier
Registration Dossier
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EC number: 500-004-7 | CAS number: 9003-29-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The results of two valid studies on skin irritating properties of 1 -Hexadecene and a blend of C16/C18 olefins indicate
that the substances may cause mild skin irritation. However, the determined Draize scores don´t lead to a classification
according to the Directive (EC) 67/548.
Based on the categorisation, skin irritation studies of olefins ranging fromC6 - C18 are regarded.Most available data show that, under 4-hr semi-occluded conditions, C6-C18 alpha and internal olefins are only mildly irritating to rabbit skin When current testing guideline recommendations (OECD 404) were used, only two of the olefines tested (C10 and C12 alpha olefins) produced 24-72 hr scores for erythema or edema >=2.
When tested under more extreme conditions (24-hr exposure, abraded skin, occluded dressing), several alpha and internal olefins caused irritation. The results of two valid studies on eye irritating properties of 1 -Hexadecene and a blend of C16/C18 olefins indicate that the substances may caus mild eyeirritation. Similar to the results of skin irritation, the Draize scoresobtained don´t lead to a classification according to the Directive (EC)67/548. Eye irritation studies of C6 -C18 olefins give the same results.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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