Registration Dossier
Registration Dossier
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EC number: 618-804-0 | CAS number: 919-94-8
Endpoint summary
Administrative data
Description of key information
Additional information
No bioconcentration tests are available for TAEE, but data are available for the structurally related aliphatic ether MTBE (see reporting format for the analogue approach as attached to the respective IUCLID entry). Whole-body bioconcentration factors (BCF) of 1.5 and 1.4 l/kg were reported for Japanese carp (Cyprinus carpio) exposed to 10 and 80 mg/l MTBE in a flow-through system at 25 ºC. Fish exposed for 28 days and then transferred to clean water eliminated almost all MTBE residues within 3 days (Fujiwara et al., 1984). However, as TAEE has a higher log Kow than MTBE (3.15 and 1.06, respectively), it is expected that the bioaccumulation of TAEE will be higher than the bioaccumulation observed for MTBE. QSAR calculations have been performed for both substances using the program BCFWIN™ v3.00 (U.S. EPA 2008c) (see QMRF and QPRF as attached to the respective IUCLID entry). For TAEE the estimated BCF was 55.6 l/kg, for MTBE it was 2.32 l/kg. As the calculated BCF for TAEE and MTBE differ approximately a factor of ca. 25, this factor is used as the safety factor for the experimental BCF of TAEE. The experimental BCF was 1.5 l/kg for MTBE and thus, a BCF in fish of 37.5 l/kg for TAEE is used in the assessment.
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