Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-070-5 | CAS number: 115-19-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
2-Methylbut-3-yn-2-ol is miscible with water. Based on the partition coefficient (log Pow) of 0.318, significant accumulation in biological tissues is not expected. Considering the high vapor presssure (20 hPa), exposure by inhalation is possible.
No studies analyzing kinetics and metabolism are available. However, from the toxicity studies mentioned in chapter 7.2 -7.8, it can be assumed that 2-Methylbut-3-yn-2-ol will be absorbed via the gastrointestinal tract and the respiratory tract. Dermal absorption must be low as no systemic toxicity was observed at a dose of 2,000 mg/kg b.w. while after acute oral exposure the LD50 in the same species (rat) is significantly lower (1,420 mg/kg b .w.).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
