Registration Dossier
Registration Dossier
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EC number: 204-070-5 | CAS number: 115-19-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report - 2-Methylbut-3-yn-ol
- Author:
- BASF AG
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Internal methods which were in large part similar to the methods described in OECD Guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylbut-3-yn-2-ol
- EC Number:
- 204-070-5
- EC Name:
- 2-methylbut-3-yn-2-ol
- Cas Number:
- 115-19-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 2-methylbut-3-yn-2-ol
- Details on test material:
- - Analytical purity: 98.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 242 g (male), 185 g( female)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 16, 20%
- Amount of vehicle (if gavage): 10 ml/kg bw - Doses:
- 0.2, 1.25, 1.6, 2.00 ml/kg bw (= ca. 172, 1076, 1377, 1722 mg/kg bw)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and mortality
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.65 mL/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 420 mg/kg bw
- Mortality:
- 2.000 ml/kg bw: 8/10 within 48 h; 10/10 within 7 days
1.60 ml/kg bw: 4/10 within 24 h
1.25 ml/kgbw : 1/10 within 24 h
0.20 ml/kg bw: 0/10 within 7 days - Clinical signs:
- other: 1.60 -2.00 ml/kg bw: - shortly after application: staggering, apathy, dyspnea, abdominal and lateral position, - after 10 -30 minutes: narcosis - after 5 h: narcosis, discharge of the eyes - 48 h: abdominal and lateral position, narcosis - days 3-4: int
- Gross pathology:
- - 3x hydrothorax, collapse of lung, blood in renal capsule, blood in urine at 2.0 ml/kg bw
- organs: no effects
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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