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EC number: 239-387-8
CAS number: 15356-60-2
Mean body weights of the dosed rats and
mice were slightly lower than those of corresponding controls. No other
clinical signs related to administration of DL-menthol were noted in any
dosed groups of rats and mice. Survival at the end of the bioassay was
at least 62% in all dosed and control groups of animals of each species,
and sufficient numbers of animals were at risk for the development of
In male rats, no tumours occurred at incidences which were considered to
be associated with the administration of DL-menthol.
In female rats, no tumours occurred at higher incidences in dosed groups
than in control groups. Fibro adenomas of the mammary gland occurred at
lower incidences in the low-dose (10/49) and high-dose (7/49) groups
than in the control group (20/50), and alveolar/bronchiolar adenomas or
carcinomas of the lung occurred only in the controls (3/50).
The acute oral LD50 of menthol in
Osborne-Mendel rats has been reported as 3,180 mg/kg body weight (Jenner
et al., 1964) and as 2,900 mg/kg body weight (Herken, 1961).When
administered in the diet to male and female rats for 5.5 weeks, D- or
DL-menthol at 100 or 200 mg/kg body weight caused no adverse effects on
gain in weight (Herken, 1961). No long-term studies have been reported
previous to the present bioassay.
It is concluded that under the conditions of this bioassay, DL-menthol
was not carcinogenic for either Fischer 344 rats or B6C3F1 mice.
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