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EC number: 239-387-8
CAS number: 15356-60-2
F : Reading after instillation of oculoguttae fluoresceini
Left eye treated with 50% HR 89/620005
Right eye treated with the vehicle
The primary eye irritant effect of “HR 89/620005’ in a 50% solution
(1:1) (w/w) was investigated according to the method recommended in the
OECD Guideline No.405,“Acute Eye Irritation/Corrosion”, Feb. 1987. The
basic method was extended to include treatment with a vehicle control in
the opposite eye to be desed with tha test article.
Under the experimental conditions described in the authorized report,
moderate to intense reactions of cornea and conjunctiva were seen in all
the rabbits after treatment with both the test article and the vehicle.
The following mean values, based on the results from the 24-, 48- and
72-hour readings, were calculated:
As it can be seen from the data shown above, the test article
formulation was more eye-irritating compare to the vehicle control.
According to the Official Journal of the European Communities, L 257,
1983, “HR 89/62005” in a 50% solution (w/w) shall not be classified as
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