Registration Dossier
Registration Dossier
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EC number: 223-981-9 | CAS number: 4151-51-3
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
In accordance with column 2 of REACH Annex VIII, a study does not need to be conducted as the substance is highly insoluble in water.
But rapid hydrolysis (as for isocyanates in general) is considered for the substance. The hydrolysis products are mainly insoluble oligomeric and polymeric ureas. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.
Using a read-across study from a chemically related substance it can be concluded that the test item undergoes a complete hydrolysis reaction in demineralized water within 24 hours and remains as hydrolysis product in form of an undissolved solid residue.
Biodegradation
The substance is considered to be "Not Readily Biodegradable".
Bioaccumulation
In accordance with column 2 of REACH Annex IX, the bioaccumulation in aquatic species study does not need to be conducted as direct or indirect exposure of the aquatic compartment does not occur.
Further according to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Due to the high reactivity of the isocyanates with water, bioaccumulation tests can in principle not be performed with these substances. Rapid hydrolysis of the substance (and isocyanates in general) makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation.
The hydrolysis products are mainly insoluble, inert oligomeric and polymeric ureas and thus not bioavailable. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.
Adsorption / desorption
The estimated carbon partition coefficient for the substance has no scientific meaning due to the reactivity of the substance with water (interstitial pore water). It is assumed that equilibrium partitioning to soil and associated organic matter is an irrelevant fate mechanism. As the substance will be rapidly reacted with associated pore water, adsorbed water, and organic matter associated with soil particles, no accumulation is expected in soil.
Henry's Law Constant
The Henry’s law constant (HLC) is directly calculated as a ratio of the vapour pressure to the water solubility yielding 0.621 Pa m3 mol at 20°C, indicating that the substance is low volatile from surface waters.
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