Registration Dossier
Registration Dossier
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EC number: 216-957-4 | CAS number: 1708-29-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
- Principles of method if other than guideline:
- According to internal BASF guideline
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,5-dihydrofuran
- EC Number:
- 216-957-4
- EC Name:
- 2,5-dihydrofuran
- Cas Number:
- 1708-29-8
- Molecular formula:
- C4H6O
- IUPAC Name:
- 2,5-dihydrofuran
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dihydrofuran
- Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 8 days
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: Irreversible effects on the eye were observed 8 days after exposure
- Irritant / corrosive response data:
- After 1 hour: Chemosis, conjunctivae and slight corneal opacity were observed.
After 24 hours: Chemosis, conjunctivae and corneal opacity were observed.
After 8 days: Conjunctivae, slight corneal opacity and scars were observed.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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