Registration Dossier
Registration Dossier
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EC number: 216-957-4 | CAS number: 1708-29-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF internal standardized method: Two rabbits per dose exposed orally to the test substance. Necropsy performed on the animals that died.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-dihydrofuran
- EC Number:
- 216-957-4
- EC Name:
- 2,5-dihydrofuran
- Cas Number:
- 1708-29-8
- Molecular formula:
- C4H6O
- IUPAC Name:
- 2,5-dihydrofuran
- Details on test material:
- - Name of test material (as cited in study report): 2,5-Dihydrofuran
- Purity: 94%
- Physical state: colorless clear iquid
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Aqueous emulsion of Tragacanth
- Doses:
- 0.4, 0.5, 1.0 mL/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 0.5 - <= 1 mL/kg bw
- Based on:
- test mat.
- Mortality:
- - No mortality observed in animals exposed to 0.4 and 0.5 mL/kg.
- All animals exposed to 1 mL/kg died, within 24 hours after exposure. - Clinical signs:
- other: - Loss of apetite observed in animals exposed to 1.0 mL/kg - In one animal, exposed to 0.4 or 0.5 mL/kg, a temporary lack of appetite, convulsive trembling, apathy and diarrhea were observed.
- Gross pathology:
- At the necropsy a histologically detectable extensive submucosal bleeding of the stomach was observed, in one of the animals that died
- Other findings:
- - Histopathology: Kidney damage was observed
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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