Registration Dossier
Registration Dossier
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EC number: 214-275-1 | CAS number: 1119-34-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Toxicokinetic assessment
- Adequacy of study:
- key study
- Study period:
- April 2012 to May 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Toxicokinetic assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Toxicokinetic assessment, based on
- Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance
- ECB EU Technical Guidance Document on Risk Assessment, 2003 - GLP compliance:
- no
Test material
- Reference substance name:
- (+)-L-arginine hydrochloride
- EC Number:
- 214-275-1
- EC Name:
- (+)-L-arginine hydrochloride
- Cas Number:
- 1119-34-2
- Molecular formula:
- C6H14N4O2.ClH
- IUPAC Name:
- (2S)-2-amino-5-carbamimidamidopentanoic acid hydrochloride
Constituent 1
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- Oral route: 100%. Dermal route: 10 %. Inhalation route: 100 %
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: The absorption factors for risk assessment purposes have been set as follows: absorption oral 100%, absorption dermal 10% and absorption inhalation 100 %
For risk assessment purposes:
Absorption oral: 100%,
Absorption dermal: 10%
Absorption inhalation: 100 %
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