Registration Dossier
Registration Dossier
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EC number: 908-531-8 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- a sub-chronic toxicity study (90 days) by the oral route does not need to be conducted because an appropriate inhalation study is available and inhalation is the most appropriate route of administration as based on the provided thorough and rigorous exposure assessment
- Justification for type of information:
- For this endpoint, an analysis based on the components is performed. Based on SIDS report on Sodium carbonate () and sodium hydroxide () and a EU-RAR on sodium hydroxide, no repeated toxicity has to be taken into account whatever the route of administration. Based on Na2S registration data, no NOAEL could be derived from the available study (Cromwell et al, 1979, Effect of copper sulphate, copper sulphide and sodium sulphide on performance and copper stores of pigs).
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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