Bis(2,4,4-trimethylpentyl)phosphinic acid

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

experimental study planned

Justification for type of information:

TESTING PROPOSAL ON INVERTEBRATE ANIMALS

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out : bis(2,4,4-trimethylpentyl)phosphinic acid

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Available GLP studies : none
- Available non-GLP studies: none
- Historical human data: not applicable
- (Q)SAR: not available
- In vitro methods: not available
- Weight of evidence: no other data is available and a weight of evidence is not applicable.
- Grouping and read-across: no read across data available
- Substance-tailored exposure driven testing: significant exposure may not be excluded
- Approaches in addition to above [if applicable]: no
- Other reasons [if applicable] : no

CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- the specific adaptation possibilities are not adequate. The information requirements for a substance as proposed by REACH may be modified based on information on exposure (i.e. triggering or waiving of further testing). In general, further testing is proposed if the CSA indicates the need to investigate further the effects on aquatic organisms, which implies long-term testing on fish and long-term testing on invertebrates for substances covered by Annex VIII and Annex IX to REACH. For fish, an EC50(96h) >22 mg/l was considered for the evaluation of the chemical safety assessment. while the EC50(48h) for daphnia magna was > 9.9 mg/l). Based on the available short-term studies, Daphnia was considered as the most sensitive species for the chemical safety assessment. The PEC/PNEC was in any case determined to be <1 for all the exposure scenarios.

FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed: OECD 211 methodology

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2,4,4-trimethylpentyl)phosphinic acid

EC Number:

280-445-7

EC Name:

Bis(2,4,4-trimethylpentyl)phosphinic acid

Cas Number:

83411-71-6

Molecular formula:

C16H35O2P

IUPAC Name:

bis(2,4,4-trimethylpentyl)phosphinic acid