Registration Dossier
Registration Dossier
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EC number: 221-742-3 | CAS number: 3218-36-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP and guideline mentioned. Basic data are given in the study report summary.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Method according: Draize J. h., Woodard G.C. and Calvery H. O., J. Pharmacol. Expt. Therapeut 82: 377 (1944)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-phenylbenzaldehyde
- EC Number:
- 221-742-3
- EC Name:
- p-phenylbenzaldehyde
- Cas Number:
- 3218-36-8
- Molecular formula:
- C13H10O
- IUPAC Name:
- [1,1'-biphenyl]-4-carbaldehyde
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese white rabbit (male)
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data
- Observation period:
- No data
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM: : Primary Irritation Index (P.I.I) of the chemical evaluated based on skin changes appearing at 24 hours and 72 hours after application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 hours and 72 hours after application
- Score:
- 1.2
- Reversibility:
- fully reversible within: 72 hours to 192 hours after application
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. The test substance is thus, classified as slightly irritating.
- Executive summary:
A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. The test substance is thus, classified as slightly irritating. Every skin changes on the 6 rabbits return to normal during the 72 hours to 192 hours after application.
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