Registration Dossier
Registration Dossier
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EC number: 404-360-3 | CAS number: 119313-12-1 CG 25-369; IRGACURE 369; TK 11-319
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Type:
- log Pow
- Partition coefficient:
- 2.91
- Temp.:
- 25 °C
- pH:
- 6.1
- Conclusions:
- The partition coefficient of test substance was determined to be logPow =2.91 at 25 °C at pH 6.1
- Executive summary:
In this guideline (OECD 107) study, the partition coefficient of the test material (EC 404-360-3) was determined to be Log Pow =2.91 at 25 °C at pH 6.1
Reference
- Preliminary estimation of the partition coefficient:
logPow= 3.98 (neutral, undissociated molecule); calculated by the fragment method of C. Hansch and A. Leo, computer program CLOGP 3.4
- Due to the fact that a first extraction experiment was carried out, in which some test substance and an unknown amount of impurities is eliminated, these substances are missing in the mass balance based on the actual weigh-in.
FINAL RESULTS
Partition Coefficient n-Octanol/aqu. phase at pH = 6.1
Overall mean value of n = 6 determinations
Pow= 821 ± 71 (Std.dev.)
log Pow = 2.91
Range: 2.95 ÷ 2.88
Description of key information
Study conducted to recognised testing guideline.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.91
- at the temperature of:
- 25 °C
Additional information
The partition coefficient was determined by shake-flask method
logPow= 2.91 at 25°C at pH 6.1
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