Registration Dossier
Registration Dossier
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EC number: 221-259-8 | CAS number: 3048-64-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Comparable to guideline study. Well documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative acute toxicity and primary irritancy of the ethylidene and vinyl isomers of norbornene.
- Author:
- Ballantyne B, Myers R and Klonne D.
- Year:
- 1 997
- Bibliographic source:
- J. Applied Toxicology 17, 211-221.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-vinylnorborn-2-ene
- EC Number:
- 221-259-8
- EC Name:
- 5-vinylnorborn-2-ene
- Cas Number:
- 3048-64-4
- Molecular formula:
- C9H12
- IUPAC Name:
- 5-ethenylbicyclo[2.2.1]hept-2-ene
- Reference substance name:
- 5-vinyl-2-norbornene
- IUPAC Name:
- 5-vinyl-2-norbornene
- Details on test material:
- - Test substance: 5-vinyl-2-norbornene (CAS 3048-64-4)
- Purity: >99%
- Source: Union Carbide Corporation, South Charleston, West Virginia
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: between 200-300 grams
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Animals were dosed orally by gavage (liquid).
- Doses:
- 1.25, 2.5, 5, 7.1, 10, 19.9 ml/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: daily. Weighed 7 and 14 days after dosing.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 239 mg/kg bw
- 95% CL:
- 4 539 - 6 127
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 567 mg/kg bw
- 95% CL:
- 5 950 - 187 368
- Clinical signs:
- other: Clinical signs of toxicity were observed in dose groups. At the lowest dose, these were limited to sluggishness and unkemp appearance. At higher doses, also seen were lacrimation, kyphosis, unsteady gait and diarrhea, which appeared within 30-45 min pos
- Gross pathology:
- The only consistent finding at necropsy of rats that died was mottled dark pink or red lungs. No gross pathology was seen in survivors at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 values indicate a low degree of toxicity. Females had a LD50 value numerically about twice that for males. The marginally significant difference in LD50 values between males and females were due mainly to the greater variability of females to the peroral toxicity of ENB.
- Executive summary:
Ballantyne et al (1997) published acute oral LD50 values of ~5200 mg/kg (males) and 10500 mg/kg (females) for vinyl norbornene in rats.
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