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EC number: 291-807-9
CAS number: 90480-71-0
The key study for acute oral toxicity was read across from the structural analogue hexadecanol (CAS 36653-82-4). It reports an LD50 value >2000mg/kg (Hempstoc k, 1996; rel 1). The key study for acute inhalation toxicity is read across from tetradecanol (CAS 112-72-1). A 1 hour LC50 of >1.5mgl was reported, which is the equivalent of 0.375 mg/l for a 4 hour exposure (Scientific Associates, 1977; rel 2). The acute dermal key study is also read across from tetradecanol, with the LD50 value of ca. 8000 mg/kg (Scientific Associates, 1977; rel 2).
There was no available data for acute toxicity for 1 -pentadecanol.
Therefore, key information from structurally related compounds was read
across for hazard decisions. For this purpose, data from hexadecanol and
tetradecanol was used.
The study for acute inhalation toxicity was selected as
read across from 1-tetradecanol as it was the structurally most
analogous substance available with the most recent and high reliability
information. The reported LC50 value for the study is below the
concentration necessary for classification purposes. Furthermore, the
saturated vapour concentration (calculated by the reviewer using the
ideal gas equation on the basis of the physicocemical properties of
1-tetradecanol) demostrates that the highest theoretically achievable
vapour concentration would have been reached or exceeded in this study
(4h LC50 value of 0.375 mg/l). Therefore the recorded concentration in
the key study represents the highest possible exposure concentration and
can be considered for classification purposes.
The data read across from reliable sources of structural analogues
suggests that classification and labelling is not required for any of
the acute toxicity endpoints, in accordance with CLP (EC regulation
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