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EC number: 234-858-4 | CAS number: 12037-47-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) > 100 mg/L (OECD 203), RA
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity to fish of Silicon orthophosphate (CAS No. 12037-47-7) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read-across, a read-across was conducted based on the products of dissociation. The read across is explained within the read across justification in section 13.
Silicon orthophosphate is readily soluble in water, dissociating into silicon and phosphate ions. Consequently, the chemical assessment is based on the products of dissociation. The substances which were chosen for the read across approach yield the same ions as the target substance (either ionic silicon or ionic orthophosphate) when dissolved in water. Data from phosphoric acid, potassium salt (2:3), dihydrate (CAS No. 6922-99-4) are used to cover the short-term toxicity to fish of the phosphate moiety of the substance. Data from silicon dioxide (CAS No. 17631 -86 -9) are used to cover the silicon moiety of the substance.
Phosphoric acid, potassium salt (2:3), dehydrate (CAS No. 6922-99-4) was tested in a 96 h limit test according to OECD 203 (GLP) with rainbow trout (Oncorhynchus mykiss) as test organism (Priestly and Mullee, 2010). At a nominal test concentration of 100 mg/L, no mortality occurred in the control and test groups. Analysis of the test preparations at 0, 24 and 96 h showed measured test concentrations to range from 109% to 118% of nominal. Therefore, an LC50 (96h) > 100 mg/L (nominal) was assumed.
Silicon dioxide (CAS No. 7631 -86 -9) was tested in a 96 h GLP-guideline study according to OECD 203 without analytics (Hooftman and van Drongelen-Sevenhuijsen, 1992). Zebra fish (Brachydanio rerio) were exposed to test suspensions at nominal 1,000 and 10,000 mg/L that were used after settling. As no mortality or adverse effects occurred in the control and test groups, an LL0 (96h) = 10,000 mg/L was assumed.
Therefore, based on the read across approach an LC50 (96h) > 100 mg/L can be assumed for silicon orthophosphate.
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