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EC number: 225-266-7 | CAS number: 4747-21-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
N-Methylisopropylamine (MIPA) is a yellowish liquid with a density of 0.704 g/cm3, a boiling point of 50 - 53°C and a molecular weight of 73.14 g/mol. MIPA has a vapour pressure of 286 mbar (20°C) and is miscible with water resulting in alkaline solutions.
In an acute oral toxicity study in rats 100% mortality was observed in three female animals dosed with 2000 mg/kg bw (BASF SE 10A0834/079067, 2008). At 300 mg/kg bw, no mortality but clear clinical signs of toxicity (e.g. impaired general state, piloerection, red to orange-red discoloration of urine etc.) were observed.
In an acute inhalation toxicity study with rats (BASF SE 1310834/077016, 2008) four of five female and all the male animals died at 10.12 mg/L.At 4.99 mg/L, no mortality occurred and the animals showed toxic effects in the respiratory tract but no systemic toxicity.
In a 28-day gavage study in rats (BASF SE, 30S0413/08036, 2009) with doses of 0, 100, 300 and 1000 mg/kg bw/d, the hydrochloride of N-Methylisopropylamine (MIPA-HCl; CAS Nr. 54565-61-6) was tested. In this study, minor signs of general systemic toxicity were observed in males and no test substance related findings were observed in females. In a 90-day gavage study in rats (BASF SE 50C0413/08S001, 2011) with MIPA-HCl, doses of 0, 100, 300 and 1000 mg/kg bw/d were tested; changes in clinical pathology parameters (increased cholesterol levels in both sexes, increased potassium- and triglyceride Ievels in female animals) were observed at the high dose level.
Based on the results of these studies as well as on the structure, the molecular weight and the physico-chemical properties, MIPA can be considered to be bioavailable.
If not excreted unchanged, MIPA might be metabolized by hydroxylation of the alkyl-groups followed by consequent oxidative desalkylation. In addition, direct acetylation of the amino-group of the molecule may occur. There are no indications of reactivity with biomacromolecules of MIPA or the formation of reactive metabolites from the present
data on genotoxicity (Ames-Test: BASF SE 40M0834/074117, 2008; in vitro cytogenicity: BASF SE 32M0834/074124, 2008)
Due to its low molecular weight, its structure as well as its vapour pressure, MIPA is expected to be excreted via exhalation and via the urine. Based on the results of the subacute toxicity study in rats, the physico-chemical properties and the water solubility, accumulation of MIPA can be excluded.
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