N-methylisopropylamine

Endpoint summary

Additional information

The most sensitive organism regarding acute toxicity to N-methylisopropylamine was Danio rerio (fish; 96 -h LC50 = 48.5 mg/L). The EC50 for alga and Daphnia were greater than 100 mg/L. Regarding long-term toxicity the NOEC was lower for aquatic invertebrates (Daphnia magna) than for algae and fish (Danio rerio), but at all three trophic levels no long-term toxicity is expected since the NOECs were greater than 1 mg/L (fish: 28 -d NOEC > 323 mg/L; algae: 72 -h NOEC = 5 mg/L; aq. invertebrates: 21 -d NOEC = 3.25 mg/L).

Short-term toxicity to fish:

Acutely harmful to fish.

The toxicity of N-methylisopropylamine (CAS 4747 -21 -1) to fish was investigated in a GLP guideline study according to OECD 203 (BASF SE, 2008, report no. R2008CN032 -02). The 96 -h LC50 was determined to be 48.5 mg/L (measured conc., Danio rerio, static system). The test solutions were probably pH-adjusted.

Long-term toxicity to fish:

Long-term toxicity not expected (NOEC > 1 mg/L).

The long-term toxicity to fish was tested in a GLP guideline study according to OECD 215 (fish, juvenile growth). The test species was Danio rerio. The test concentrations were analytically measured. They deviated by more than 20% from nominal values, therefore the effect values are related to mean measured concentrations. The highest test concentration was 323 mg/L. The pH varied between 6.95 and 7.40. The 28-d NOEC was determined to be > 323 mg/L related to growth rate (mean measured concentrations; BASF SE, 2011; report no. R1101100174B). It can be concluded that long-term toxicity is not expected.

 

Short-term toxicity to aquatic invertebrates:

With high probability acutely not harmful to aquatic invertebrates.

An EC50 of >100 mg/L was determined in a GLP study testing the toxicity of N-methylisopropylamine to Daphnia magna conducted according to OECD 202 (BASF SE, 2009, report no. 50E08354/073490). The test item concentrations were analytically verified. The test solutions were pH-adjusted.

Long-term toxicity to aquatic invertebrates:

Long-term toxicity not expected (NOEC > 1 mg/L).

The long-term effect on aquatic invertebrates was investigated in a GLP guideline study according to OECD 211 (Daphnia magna reproduction test). The test concentrations were analytically verified. The effect values are related to measured concentrations (time-weighted average). The pH vaired between 6.32 to 8.16. The 21 -d NOEC was determined to be 3.25 mg/L (BASF SE, 2011; Report no. R1101100174A). Chronic toxicity is therefore not expected.

 

Toxicity to aquatic algae and plants:

With high probability acutely not harmful to aquatic algae.

In a guideline study according to OECD 201, the toxicity of N-methylisopropylamine (CAS 4747 -21 -1) to the green alga Desmodesmus obliquus was investigated (BASF SE, 2008, report no. R2008NC032 -01). The 72 -h ErC50 was determined to be 131 mg/L, the NOEC 5 mg/L. The test item concentrations were not analytically verified, but are assumed to be stable.

Toxicity to microorganisms:

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.

The toxicity to microorganisms was investigated according to OECD 209 using activated sludge from a municipal wwtp. The 180 -min EC10 was determined to be 160 mg/L (BASF SE, 2010; report no. 08G0396/09G004). The test solutions were pH-adjusted.