Uronium hydrogen sulphate

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Results of the investigation of 200 chemical compounds for acute fish toxicity with the Golden Orfe test [Ergebnisse der Untersuchung von 200 chemischen Vergindungen auf akute Fischtoxizitat mit dem Goldorfentest]

Author:

Juhnke, I. & Ludemann, D.

Year:

1978

Bibliographic source:

Zeitschrift fuer Wasser und Abwasser Forschung 11(5): 161-164

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: German Unified Methods for Investigation of Water, Wastewater and Sludge. L15. Fish test. Vom Wasser 46:291-295(1976)

Principles of method if other than guideline:

Acute toxicity to freshwater fish

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Urea

EC Number:

200-315-5

EC Name:

Urea

Cas Number:

57-13-6

Molecular formula:

CH4N2O

IUPAC Name:

urea

Details on test material:

Urea

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Not applicable

Sampling and analysis

Analytical monitoring:

not specified

Details on sampling:

No information available

Test solutions

Vehicle:

not specified

Details on test solutions:

No information available

Test organisms

Test organisms (species):

Leuciscus idus melanotus

Details on test organisms:

Leuciscus idus melanotus; golden orfe

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Post exposure observation period:

No information available

Test conditions

Hardness:

No information available

Test temperature:

No information available

pH:

No information available

Dissolved oxygen:

No information available

Salinity:

No information available

Nominal and measured concentrations:

No information available

Details on test conditions:

The test was conducted at two different laboratories; the Institute for Water, Soil and Air Hygiene of the Federal Health Office, Berlin; and at the State Institute for Water and Waste, NW.

Reference substance (positive control):

not specified

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 10 000 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

mortality (fish)

Effect concentrations 2

Duration:

48 h

Dose descriptor:

LC0

Effect conc.:

> 10 000 mg/L

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

mortality (fish)

Details on results:

No information available

Results with reference substance (positive control):

No information available

Reported statistics and error estimates:

No information available

Any other information on results incl. tables

Sublethal observations / clinical signs:

The 48 hour LC₅₀ of urea in golden orfe fish is >10000 mg/l. This can also be considered as the NOEC. The results reported by the two laboratories were identical.

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

The 48 hour NOEC of urea in fish >10000 mg/l; urea is not acutely toxic to fish.

Executive summary:

The 48 hour LC₅₀ of urea in golden orfe fish is >10000 mg/l. This can also be considered as the NOEC. The results reported by the two laboratories were identical. It can be concluded that urea is not acutely toxic to fish.