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EC number: 291-454-0
CAS number: 90411-76-0
It has to be clarified that the positive levels are exclusively defined
for the NMRI mice used for this study:
The positive level of ear swelllling which is 2x10 [exp -2] mm increase
, i.e. about 10 % of the control values, has not been reached or
exceeded in any dose group.of the test item whereas the respective value
of the positive control has shown a statistical significant increase.
Body weights of the animals was not affected by any treatment.
A LLNA/IMDS was carried out in female NMRI mice after epicutaneous
application of formulation
containing 0%, 2 %, 10 %, or 50 % of the test item Nigrosin WLF
dissolved in Methylethylketon (MEK) for 3 consecutive days
onto both ears of the animals. The study was conducted according to OECD
TG No. 429 and No. 406.
Nigrosin WLF showed no sensitizing potential in the modified Local Lymph
Node Assay (IMDS) in female NMRI mice after dermal application of up to
and including a 50 % concentration. Additionally, no indication for a
non-specific(irritant) activation by the test item was detected. The
positive control hexyl cinnamic aldehyde (CAS-No. 101 -86 -0) was
functional for each parameter (Vohr 2012)..
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