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EC number: 271-085-1
CAS number: 68515-43-5
The phthalate esters are1,2-benzenedicarboxylic acids with side chain
esters ranging in carbon chain length from C1 to C13.The US EPA High
Production Volume (HPV) chemical challenge program has proposed grouping
phthalate esters into a single category, divided into 3 sub-categories,
this based on the structural similarities of the substances and their
physicochemical and toxicological properties. These sub-categories are:
low molecular weight phthalates, transitional phthalates, and high
molecular weight phthalates. The high molecular weight phthalates are
defined as being produced from alcohols with straight-chain carbon
backbones of >C7 or a ring structure. These include varying mixed
isomers of linear and branched diheptyl, dioctyl, dinonyl, didecyl,
diundecyl and ditridecyl phthalate. All exhibit low solublity in water
and are regarded as being too insoluble to exhibit acute or chronic
toxicity. Read-across from closely related phthalates thus appears
reasonable and this is supported by the data, below:
Studies of sensitisation with the substance (chain length C9-C11) give
no indication that the substance is a sensitiser.
The same findings occurred in better documented studies on phthalate
esters with chain lengths of C11, C8-C10 and C10-C12-C14.
Non classification is justified as there is no evidence of sensitisation
occurring in animal models.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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