Acetamide, N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)-

Guidance on Safe Use

First-aid measures

Description of first aid measures

General advice: Move out of dangerous area. Place and transport victim in stable position (lying sideways). Remove contaminated clothing immediately and dispose of safely. Call a physician or poison control center immediately.

Inhalation: Move to fresh air. Keep patient warm and at rest. Call a physician or poison control center immediately.

Skin contact: Do not pull solidified product from skin. Call a physician or poison control center immediately. Wash off thoroughly with plenty of soap and water, if available with polyethyleneglycol 400, subsequently rinse with water.

Eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a physician or poison control center immediately.

Ingestion: Rinse mouth. Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and effects, both acute and delayed

Symptoms: To date no symptoms are known.

Indication of any immediate medical attention and special treatment needed

Treatment: Treat symptomatically. In case of ingestion gastric lavage should be considered in cases of significant ingestions only within the first 2 hours. However, the application of activated charcoal and sodium sulphate is always advisable. There is no specific antidote.

Fire-fighting measures

Extinguishing media

Suitable: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Unsuitable: High volume water jet

Special hazards arising from the substance or mixture: In the event of fire the following may be released:, Hydrogen cyanide (hydrocyanic acid), Hydrogen fluoride, Carbon monoxide (CO), Nitrogen oxides (NOx)

Advice for firefighters

Special protective equipment for firefighters: In the event of fire and/or explosion do not breathe fumes. In the event of fire, wear self-contained breathing apparatus.

Further information: Contain the spread of the fire-fighting media. Do not allow run-off from fire fighting to enter drains or water courses.

Accidental release measures

ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures

Precautions: Avoid contact with spilled product or contaminated surfaces. Use personal protective equipment.

Environmental precautions: Do not allow to get into surface water, drains and ground water. Do not contaminate surface or ground water by cleaning equipment or disposal of wastes, including equipment wash water.

Methods and materials for containment and cleaning up

Methods for cleaning up: Allow to solidify. Use mechanical handling equipment. Collect and transfer the product into a properly labelled and tightly closed container. Clean contaminated floors and objects thoroughly, observing environmental regulations.

Handling and storage

Manufacture and use takes place under strictly controlled conditions. The substance is rigorously contained (production, use), appropriate risk management measures are applied and a management system is in place. An authorisation scheme covers the process and a procedure ensures that only trained and authorised persons handle the substance. Process procedures for containment during cleaning and maintenance have been accounted for in plant and engineering design as appropriate for the site. Procedures to ensure containment have been applied for all stages of production and processing. Occupational procedures have been assessed and are documented.

HANDLING AND STORAGE

Precautions for safe handling

Advice on safe handling: Use only in area provided with appropriate exhaust ventilation. Handle and open container in a manner as to prevent spillage.

Advice on protection against fire and explosion: No special precautions required.

Hygiene measures: Avoid contact with skin, eyes and clothing. Keep working clothes separately. Wash hands before breaks and immediately after handling the product. Remove soiled clothing immediately and clean thoroughly before using again. Garments that cannot be cleaned must be destroyed (burnt).

Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containers: Store in original container. Store in a place accessible by authorized persons only.

Advice on common storage: Keep away from food, drink and animal feedingstuffs.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

3256

Shipping information

Proper shipping name and description:

ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. (ACETAMIDE,N-(4-FLUOROPHENYL)-2-HYDROXY-N-METHYLETHYL,TOLUENE)

Chemical name:

N-(4-Fluorphenyl)-2-hydroxy-N-(1-methylethyl)acetamid

Language:

English

Labels:

Packaging 3
Bulk 3
Haz ID 30
EAC 2Y

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

3256

Shipping information

Proper shipping name and description:

ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S.
(ACETAMIDE,N-(4-FLUOROPHENYL)-2-HYDROXY-NMETHYLETHYL, TOLUENE)

Chemical name:

N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide

Language:

English

Labels:

Packaging 3
Bulk 3
Haz ID 30

Special provisions / remarks

Remarks:

This classification is in principle not valid for carriage by tank vessel on inland waterways.

Marine transport (UN RTDG/IMDG)

UN number:

3256

Shipping information

Proper shipping name and description:

ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S.
(ACETAMIDE,N-(4-FLUOROPHENYL)-2-HYDROXY-NMETHYLETHYL, TOLUENE)

Chemical name:

N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide

Labels:

Packaging 3
Bulk 3

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

transport not permitted

Shipping

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

The DG classification as UN3256 is assigned in the case the substance is transported as molten solid, heated at t° equal or higher than its flash point of 67°C.

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with  REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4).  Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

EXPOSURE CONTROLS/PERSONAL PROTECTION

Control parameters

Components                                   CAS-No.       Control parameters              Update       Basis

N-(4-Fluorophenyl)-2-hydroxy-N-(1-methylethyl) acetamide       54041-17-7       1 mg/m3 (TWA)                     OES BCS*

Toluene                                   108-88-3       192 mg/m3/50 ppm (TWA)              12 2009       EU ELV

Toluene                                   108-88-3       384 mg/m3/100 ppm (STEL)       12 2009       EU ELV

Toluene                                   108-88-3       384 mg/m3/100 ppm(STEL)       2014       EU SCOELS

Toluene                                   108-88-3       192 mg/m3/50 ppm (TWA)              2014       EU SCOELS

Toluene                                   108-88-3       20 ppm (TLV)                     OES BCS*

*OES BCS: Internal Bayer AG, Crop Science Division "Occupational Exposure Standard"

Exposure controls

Respiratory protection: If product is handled while not enclosed, and if contact may occur: Wear respirator with an organic vapours and gas filter mask (protection factor 10) conforming to EN140 type A or equivalent.

Hand protection: Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves. Also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion, and the contact time.

Wash gloves when contaminated. Dispose of when contaminated inside, when perforated or when contamination on the outside cannot be removed. Wash hands frequently and always before eating, drinking, smoking or using the toilet.

      Material              Nitrile rubber

      Rate of permeability       > 480 min

      Glove thickness       > 0,4 mm

      Protective index       Class 6

      Directive              Protective gloves complying with EN 374.

Eye protection: Wear goggles (conforming to EN166, Field of Use = 5 or equivalent).

Skin and body protection: Wear standard coveralls and Category 3 Type 4 suit.

Wear two layers of clothing wherever possible. Polyester/cotton or cotton overalls should be worn under chemical protection suit and should be professionally laundered frequently. If chemical protection suit is splashed, sprayed or significantly contaminated, decontaminate as far as possible, then carefully remove and dispose of as advised by manufacturer.

Stability and reactivity

STABILITY AND REACTIVITY

Reactivity: Stable under normal conditions.

Chemical stability: Stable under normal conditions.

Possibility of hazardous reactions: No hazardous reactions when stored and handled according to prescribed instructions.

Conditions to avoid: Heat, flames and sparks.

Incompatible materials: No data available

Hazardous decomposition products: No decomposition products expected under normal conditions of use.

Disposal considerations

In accordance with current regulations.

During the whole life cycle of the substance all necessary measures in accordance to art. 18(4) of (EC) 1907/2006 are undertaken. The substance is handled under strictly controlled conditions.

Waste air from the process is being burnt.

Solvents are being recycled or burnt.

Mother liquors and solid waste is being burnt.

DISPOSAL CONSIDERATIONS

Waste treatment methods

Product: In accordance with current regulations and, if necessary, after consultation with the site operator and/or with the responsible authority, the product may be taken to a waste disposal site or incineration plant.

Contaminated packaging: Not completely emptied packagings should be disposed of as hazardous waste.