Decan-1-ol, ethoxylated

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented publication which meets basic scientific principles

Qualifier:

no guideline followed

Principles of method if other than guideline:

Fish were exposed in a flow-through system to the test substance during an uptake phase of up to 72 h. The following elimination phase lasted for 24 h.

GLP compliance:

no

Radiolabelling:

no

Vehicle:

no

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name: fathead minnow
- Source: hatchery of Utrecht University, The Netherlands
- Weight at study initiation (mean and range, SD): 0.5 - 1.0 g

ACCLIMATION
- Acclimation period: at least 1 week
- Type and amount of food: Lapis dry feed at a rate of 1% of body weight
- Feeding frequency: daily

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

natural water: freshwater

Total exposure / uptake duration:

54 - 72 h

Total depuration duration:

24 h

Test temperature:

20.7 - 22.5 °C

Details on test conditions:

TEST SYSTEM
- Test vessel: 5 - 8 L aquaria
- No. of organisms per vessel: 30


TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted freshwater was prepared by dissolving 0.75 mM CaCl2 x 2H2O, 0.46 mM MgSO4 x 7H2O, 1.51 mM NaHCO3, 0.04 mM KH2PO4, 1.01 mM NaNO3 and 0.10 mM Na2SiO3 in distilled water.

Nominal and measured concentrations:

The AE concentrations were higher than the critical micelle concentration. 0.029 µM steady state concentration of the test compound in water

Reference substance (positive control):

no

Lipid content:

0.9 - 8.2 %

Time point:

start of exposure

Remarks on result:

other: average content: 4.9%

Type:

BCF

Value:

12.7 L/kg

Basis:

not specified

Time of plateau:

24 h

Calculation basis:

steady state

Remarks on result:

other: for C12EO8

Remarks:

Conc.in environment / dose:0.570 µM steady state concentration of the test compound in water

Type:

BCF

Value:

237 L/kg

Basis:

not specified

Time of plateau:

24 h

Calculation basis:

steady state

Remarks on result:

other: for C14EO4

Remarks:

Conc.in environment / dose:0.029 µM steady state concentration of the test compound in water

Details on results:

- Mortality of test organisms: no mortality was observed
- Behavioural abnormalities: no signs of sublethal effects, such as swimming or breathing behavior, were observed during the experiments.

The test substance was not stored inside fish and no relationship between BCF and lipid content was observed. The elimination rate suggested rapid biotransformation of the test substance.

Description of key information

Bioaccumulation in organisms is negligible, due to biotransformation and excretion of alcohol ethoxylates.

Additional information

In a publication on the bioconcentration of alkylethoxylates Tolls et al. (2000) reported BCF-values ranging from <5 to 387.5 whereas uptake rates varied from 330 to 1660 (L x kg/d) and elimination rates varied from 3.3 to 59 per day. The authors stated that the time of steady state and the BCF for AE increase with increasing chain length of alkyl chain and decreasing length of the ethoxylate chain. The alcohol ethoxylates with alkyl-chain length comparable to the given substance are C12EO8 and C14EO4. For these alcohol ethoxylates Tolls et al. (2000) reported BCF-values of 12.7 and 237 L/kg, respectively.