Registration Dossier
Registration Dossier
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EC number: 235-185-9 | CAS number: 12125-01-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The key study for ammonium toxicity is showing a NOEC of 14.6 mg/L of NH4Cl.
On the other hand, the EU RAR summarises the effects of two reproductive studies of sodium fluoride on Daphnia magna. The two studies report NOEC values of 3.7 and 14.1 mg/L, with an arithmetic mean of 8.9 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 8.9 mg/L
Additional information
As ammonium fluoride decomposes in an aqueous environment into ammonium and fluoride ions, toxicity of these two ions has been studied and the most conservative one has been kept for assessment.
Ammonium toxicity was studied in a 21 days chronic toxicity test, in which adult Daphnia magna were exposed to various concentrations of ammonium chloride under semi-static conditions.
Analytical monitoring for concentration in NH3-N was conducted at the beginning and end of each renewal period of test solution.
Results were as follows: 21 d NOEC was 0.60 mg/L as NH3-N and was calculated as 14.6 mg/L of NH4Cl ( average of measured concentrations).
For Fluoride toxicity, the EU RAR summarises the effects of two reproductive studies of sodium fluoride on Daphnia magna. The two studies report NOEC values of 3.7 and 14.1 mg/L, with an arithmetic mean of 8.9 mg/L. The ICD reports additional EC50 values in the range of 10 - 48 mg/L which is consistent and support the key study.
In conclusion, considering the respective toxicity to aquatic invertebrates in freshwater, the most conservative NOEC for fluoride is retained as key data for hazard assessment.
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