Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Density
Administrative data
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan 2021 to 18 Mar 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- 2012
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
- Version / remarks:
- 2016
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
Test material
- Reference substance name:
- 4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Cas Number:
- 1903009-55-1
- Molecular formula:
- C27H30N8O4
- IUPAC Name:
- 4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
Batch (Lot) Number: I20HD2581
Expiry date: 15 August 2022
Physical Description: Yellow powder
Purity: 97.1%
Purity/Composition correction factor: Yes, correction factor is 1.00
STORAGE CONDITIONS
Storage Conditions: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: prior to use in the study, the test material was dried in a desiccator under vacuum using silicagel as the drying agent at 22.8 ± 0.4°C in dark for 44.8 hours
Results and discussion
Densityopen allclose all
- Type:
- relative density
- Density:
- 1.32
- Temp.:
- 20 °C
- Key result
- Type:
- density
- Density:
- 1.32 g/cm³
- Temp.:
- 20 °C
Any other information on results incl. tables
The results of the tests on the determination of the density of the test item are given in the table below
| Test 1 | Test 21 |
Sample mass (g) | 1.9574 | 1.8525 |
Sample volume (cm3) | 1.4862 1.4866 1.4850 1.4838 1.4836 | 1.4032 1.4017 1.4057 1.4011 1.4015 |
Average volume (cm3) | 1.4850 ± 0.0012 | 1.4026 ± 0.0017 |
Density (g/cm3) | 1.318 | 1.321 |
Mean Density (g/cm3) | 1.32 | |
The individual measurements were obtained with an accuracy of < 0.02 g/cm3. According to the guideline, the density of the test item is given as the mean value.
Applicant's summary and conclusion
- Conclusions:
- A gas comparison stereopycnometer was used for the determination of the density and relative density of JNJ-73848268-AAA (T003903).
The density of the test item at 20ºC was 1.32 g/cm3 (1.32E3 kg/m3).
The relative density was 1.32.
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