Lithium bis(fluorosulfonyl)imide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017.9.13~2018.1.26

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

17th DEC. 2001

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lithium bis(fluorosulfonyl)imide

EC Number:

686-526-7

Cas Number:

171611-11-3

Molecular formula:

F2 H N O4 S2 . Li

IUPAC Name:

Lithium bis(fluorosulfonyl)imide

Test material form:

solid: bulk

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other:

Details on oral exposure:

Sterile distilled water

Doses:

1

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 300 - < 2 000 mg/kg bw

Based on:

test mat.

Mortality:

The test substance-related dead animals were observed in 300 mg/kg B.W. (4th step)
1 animal(2401 : administration 1 day), 2000 mg/kg B.W. (5th step) all animals(2501 –
2503 : administration 1 h).

Clinical signs:

other: In clinical signs, lying on side(2401 : administration 2 – 4 h), hunchback position(2403 : administration 2 – 4 h), convulsion(2401 : administration 2 – 4 h)(2402, 2403 : administration 2 – 3 h) were observed in 300 mg/kg B.W. (4th step). And, death anima

Gross pathology:

In the necropsy of survived animals, there were no abnormal findings caused by
administration of the test substance. In the necropsy finding of dead animals,
cannibalism in external finding were observed in 300 mg/kg B.W. (4th step) 1
animal(2401). And, retention of test substance in the stomach in internal finding were
observed in 2000 mg/kg B.W. (5th step) all animals(2501 – 2503).

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Mortality and Clinical signs
The test substance-related dead animals were observed in 300 mg/kg B.W. (4th step)
1 animal(2401 : administration 1 day), 2000 mg/kg B.W. (5th step) all animals(2501 –
2503 : administration 1 h).
In clinical signs, lying on side(2401 : administration 2 – 4 h), hunchback position(2403 :
administration 2 – 4 h), convulsion(2401 : administration 2 – 4 h)(2402, 2403 :
administration 2 – 3 h) were observed in 300 mg/kg B.W. (4th step). And, death
animal were observed in 1 animal(2401) on day 1 administration. Besides, there were
no other clinical signs caused by administration of the test substance.

Body weight changes
In body weight of animals death except for the results, 1 animal(2101) was decreased
in 50 mg/kg B.W. (1st step) on 14 days as compared with 7 days. 1 animal(2201) was
decreased in 50 mg/kg B.W. (2nd step) on 1 day as compared with administration day.
1 animal(2303) was decreased in 300 mg/kg B.W. (3rd step) on 3 days as compared
with 1 day. The other animals showed the normal increase of body weight during the
study period.

Necropsy findings
In the necropsy of survived animals, there were no abnormal findings caused by
administration of the test substance. In the necropsy finding of dead animals,
cannibalism in external finding were observed in 300 mg/kg B.W. (4th step) 1
animal(2401). And, retention of test substance in the stomach in internal finding were
observed in 2000 mg/kg B.W. (5th step) all animals(2501 – 2503).