Registration Dossier
Registration Dossier
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EC number: 616-083-7 | CAS number: 74351-78-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study, well-documented study with acceptable restrictions e.g no details on test animals, test material.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[(2E)-2-[1-({4-[(2E)-2-[2-(5-carboxy-2-chlorophenyl)hydrazin-1-ylidene]-3-oxobutanamido]-2,5-dimethylphenyl}carbamoyl)-2-oxopropylidene]hydrazin-1-yl]-4-chlorobenzoic acid
- EC Number:
- 616-083-7
- Cas Number:
- 74351-78-3
- Molecular formula:
- C30 H26 Cl2 N6 O8
- IUPAC Name:
- 3-[(2E)-2-[1-({4-[(2E)-2-[2-(5-carboxy-2-chlorophenyl)hydrazin-1-ylidene]-3-oxobutanamido]-2,5-dimethylphenyl}carbamoyl)-2-oxopropylidene]hydrazin-1-yl]-4-chlorobenzoic acid
- Details on test material:
- - Batch No.: OP 31
- purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: males = 194 - 200 g, females = 175 - 192 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Signs and Symptoms were noted on the first 5 hours after application and then daily. Bodies were weighted on days 1, 7 and 14.
- Necropsy of survivors performed: yes, at the end of the observation period.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effects observed.
- Mortality:
- 0/6 animals
- Clinical signs:
- other: Dyspnoea, ruffled fur and curved body position were observed, being common symptoms in acute tests. The male animals recovered on day 9 and females on day 8.
- Gross pathology:
- No abnormalities detected at necropsy.
Applicant's summary and conclusion
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