6-methyloct-5-en-2-one

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

13.08. - 23.09.1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: According to OECD guideline (1992) under GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

no

Principles of method if other than guideline:

Not relevant

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

6-methyloct-5-en-2-one

EC Number:

246-073-4

EC Name:

6-methyloct-5-en-2-one

Cas Number:

24199-46-0

Molecular formula:

C9H16O

IUPAC Name:

6-methyloct-5-en-2-one

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

semiocclusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Duration of treatment / exposure:

4h

Observation period:

1, 24, 48 and 72 h after treatment

Number of animals:

1 male, 2 females

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 1

Score:

0

Max. score:

0

Results 2

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24

Score:

0

Max. score:

0

Results 3

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 48

Score:

0

Max. score:

0

Results 4

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 72

Score:

0

Max. score:

0

Other effects:

No other effects.

Any other information on results incl. tables

Observations after 1, 24, 48 and 72 h:

Erythema: NO ABNORMAL FINDINGS NOTED.

Edema: NO ABNORMAL FINDINGS NOTED.

Skin fissures: NO ABNORMAL FINDINGS NOTED.

Flaking: NO ABNORMAL FINDINGS NOTED.

Staining: NO ABNORMAL FINDINGS NOTED.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Based upon the referred classification criteria, ethylheptenone is considered to be "not
irritating" to rabbit skin.

Executive summary:

To assess the primary skin irritation potential of ethylheptenone, a primary skin irritation

study was performed in three (one male and two females) young adult New Zealand White

rabbits.

The fur of the left flank was clipped and 0.5 ml of ethylheptenone was applied

epicutaneously to an area of approximately 6 cm2 and then covered with a semi-occlusive

dressing for approximately four hours. After removal of the dressing and test article, the skin

reactions (erythema and eschar, as well as edema formation) were evaluated at 1, 24, 48 and

72 hours after application. The primary irritation score was calculated to reflect and classify

the irritant potential of the test article.

The dermal exposure to ethylheptenone did not cause dermal irritation.

The Primary Irritation Score for ethylheptenonewas 0.00 (the maximum attainable score is 8.0).

Following evaluation of the experimental data according to the EEC and GHS classification criteria, ethylheptenone is classified as "not irritating" to rabbit skin.