6-methyloct-5-en-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed according to OECD and GLP guidelines

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

not specified

Principles of method if other than guideline:

Not relevant

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

6-methyloct-5-en-2-one

EC Number:

246-073-4

EC Name:

6-methyloct-5-en-2-one

Cas Number:

24199-46-0

Molecular formula:

C9H16O

IUPAC Name:

6-methyloct-5-en-2-one

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Standard suspending vehicle: Sodium Carboxylmethylcellulose (CMC) 5 g, Tween 80 4 ml, Benzylalcohol 5 ml NaCI (0.9%) ad 1000 ml

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5 rats/sex/dose group

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

No other information

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The test substance is not acute toxic via the oral route. The LD50 (oral) is greater than 2000 mg/kg bw. Based on the criteria laid down in Regulation 1272/2008/EC, the test substance is not to be classified with regard to acute oral toxicity.

Executive summary:

The acute toxicity of ethylheptenone (Ro 02-8094/000) after oral administration

was investigated in Wistar rats of both sexes.

Single-dose administration of 2000 mg/kg body weight was well tolerated. No

mortalities occurred and no uncommon clinical signs were observed except for

slight to moderate lacrimation and slightly reduced activity for a period of about

three hours after dosing. No other clinical signs were observed during the 14-day

observation period and no treatment-related macroscopic findings were noted at

necropsy.

The maximum tolerated dose (MTD) in the rat after acute oral administration was

more than 2000 mg/kg bw, and, thus ethylheptenone can be classified as a

compound which "does not present a significant acute toxic risk if swallowed".