Registration Dossier
Registration Dossier
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EC number: 274-446-1 | CAS number: 70214-76-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 6,8-dimethylnona-3,5-dien-2-one
- EC Number:
- 274-446-1
- EC Name:
- 6,8-dimethylnona-3,5-dien-2-one
- Cas Number:
- 70214-76-5
- Molecular formula:
- C11H18O
- IUPAC Name:
- 6,8-dimethylnona-3,5-dien-2-one
Constituent 1
Method
- Target gene:
- TA1535 hisG46
TA97 hisD66100
TA98 hisD3052
TA100 hisG46
TA102 hisG428
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA1535, TA97, TA98, TA100, and TA102
- Additional strain / cell type characteristics:
- other: rfa, delta-uvrB, pKM101
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 333 and 1000 ug /plate
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- sodium azide
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other:
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
It is therefore concluded that neither Dimethylnonadienon per se, nor
any of the metabolites formed under the described experimental conditions is
mutagenic in the Ames test.
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