Registration Dossier
Registration Dossier
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EC number: 274-446-1 | CAS number: 70214-76-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 6,8-dimethylnona-3,5-dien-2-one
- EC Number:
- 274-446-1
- EC Name:
- 6,8-dimethylnona-3,5-dien-2-one
- Cas Number:
- 70214-76-5
- Molecular formula:
- C11H18O
- IUPAC Name:
- 6,8-dimethylnona-3,5-dien-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD (SD) BR strain (VAF plus)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 per sex per dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, treatment with the test article, Dimethylnonadienon
at a dose level of 2000mg/kg bodyweight produced no deaths. - Executive summary:
Since the results of the range finding study indicated that a dose level of 2000mg/kg produced
no mortality, in the main study the test article was administered at this dose level as a single
oral dose to a group of 5 male and 5 female rats which had been fasted overnight. The animals
were examined frequently on the day of dosing and daily thereafter for a further 14 days at the
end of which, they were killed and subjected to necropsy. No deaths occurred; however, all animals exhibited piloerection and hypoactivity on the day of dosing.
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