Registration Dossier
Registration Dossier
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EC number: 940-683-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
It is concluded that fatty acids, C18 (saturated and unsaturated) ethyl esters has low bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
A through evaluation of the toxicokinetic properties of "target" substance (Fatty acids, C18 (saturated and unsaturated) ethyl esters) is available in section 13.
In summary, fatty acid esters are metabolised to the fatty acids and the alcohol (ethanol in this case) and then entering the general metabolism and oxidised to carbon dioxide and water. This metabolism is mainly taking place in the liver.
Fatty acids, C18 (saturated and unsaturated) ethyl esters are likely to hydrolyse in nature at naturally occurring pH. Thus, indirect environmental exposure to the fatty acids or the alcohol (ethanol) is not likely. In the body, fatty acids, C18 (saturated and unsaturated) ethyl esters are hydrolysed enzymatically to fatty acids and the corresponding alcohol (ethanol).The fatty acids continue in the body’s normal lipid metabolism (via beta-oxidation and entering into Krebs cycle (Citric acid cylcle)) . The alcohols are biotransformed into the corresponding acids, i.e. acetic acid.
Topically applied fatty acid ethyl esters is assessed to have the capability of penetrating living cells of normal epidermis, enter into metabolism and significantly modify endogenous epidermal lipids.
In conclusion, fatty acids, C18 (saturated and unsaturated) ethyl esters has low bioaccumulation potential.
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