Registration Dossier
Registration Dossier
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EC number: 231-959-5 | CAS number: 7782-50-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publicly available literature without indication of guideline and GLP, only basic information available
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 918
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public available literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hypochlorite
- EC Number:
- 231-668-3
- EC Name:
- Sodium hypochlorite
- Cas Number:
- 7681-52-9
- Molecular formula:
- ClO.Na
- IUPAC Name:
- sodium hypochlorite
- Details on test material:
- sodium hypochlorite, commercial product Dakin's hypochlorite (bleaching powder, 0.41-0.5% NaClO) and Javelle water (0.5-1.0% NaClO)
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
Results and discussion
Effect levels
- Dose descriptor:
- other: LD
- Effect level:
- 240 - 250 mg/kg bw
Applicant's summary and conclusion
- Executive summary:
- MATERIALS AND METHODS:
Increasing doses of commercial NaClO products as Dakin´s hypochlorite (bleaching powder) were injected into mice i.p. and into guinea pigs subcutanously and i.p.
The smallest fatal dose was tested.
RESULTS AND DISCUSSION:
Dakin´s hypochlorite solution given i.p. is 2-3 times as toxic for the guinea pigs as for the mouse.
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