Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC B3
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
412-720-6
EC Name:
-
Cas Number:
156653-67-7
Molecular formula:
C26H26ClN9O12S3.2 Na
IUPAC Name:
disodium 2-[2-(5-carbamoyl-1-ethyl-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazen-1-yl]-4-{[4-chloro-6-({4-[2-(sulfonatooxy)ethanesulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}benzene-1-sulfonate

Test animals

Species:
other: rat/Wistar HOE: WISKf (SPF71)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: 0, 7 ml isotonic sodium chloride solution
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: The animals wrer free of intoxication symptoms during the test period.
Gross pathology:
Effects on organs:
The result of the section of the animal which died is a dark discolouration of the liver, blood abundance in the lung, blood in the urine and a clear liquid in the abdominal cavity. The animals which were killed after the test showed no macroscopic effects.
Other findings:
Signs of toxicity (local): One animal died at the 5 day of the study. The death of this animal was not caused by the substance. The treated skin areas were discoloured yellow during the test period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU