Registration Dossier
Registration Dossier
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EC number: 442-070-9 | CAS number: 329039-38-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h)= 1517 mg/L (nominal)(Oncorhynchus mykiss)
Key value for chemical safety assessment
Additional information
The acute toxicity of methyldiacetoxyisopropoxy silane (CAS No. 329039-38-5) to fish was investigated in a study by Eickhoff (2001), using Oncorhynchus mykiss as test species. This test was conducted according to OECD Guideline 203 (Fish, Acute toxicity), under GLP conditions. A preliminary range-finding test and four tests exposing fish to different concentrations of the substance were performed at 14 ± 2 °C for 96 hours. The concentrations of two hydrolysis products (isopropanol and acetic acid) were determined by means of GC. The results from the definitive tests showed effects in the highest concentrations (2094, 4594 and 10000 mg/L) where 70-100% mortality was observed. No mortality was recorded in the remaining treatment groups. Therefore, the LC50 (96 h) was determined to be 1517 mg/L (based on initial nominal test substance concentrations). Acute fish toxicity data from acetic acid were found to range from 49-446 mg/L (LC50s (48 h, 96 h), OECD SIDS for analogue substance Methyltriacetoxysilane (CAS No. 4253-34-3), 2005), whereas the LC50 (96 h) for isopropanol was determined to be 9640 mg/L (OECD SIDS, 1997).
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